Fredericamycin A a new antitumor antibiotic. II. Biological properties.
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چکیده
منابع مشابه
Fredericamycin A, a new antitumor antibiotic. II. Biological properties.
Fredericamycin A is a novel antibiotic produced by a soil isolate of Streptomyces griseus (FCRC-48). In vitro, fredericamycin A exhibits antibacterial, antifungal, and cytotoxic activities. In vivo, fredericamycin A exhibits very good antitumor activity against P388 mouse leukemia as well as the CD8F mammary tumor and marginal activity against B16 melanoma. Fredericamycin A failed to demonstrat...
متن کاملFredericamycin A, a new antitumor antibiotic. I. Production, isolation and physicochemical properties.
A new antitumor antibiotic, fredericamycin A (FCRC-A48, NSC-305263), has been isolated from a strain of Streptomyces griseus (FCRC-48). Based on its unique ultraviolet-visible spectrum, infrared spectrum, proton and carbon-13 nuclear magnetic resonance spectra and mass spectra, it is judged to be a novel acid-base indicator type of compound. Its production, isolation and physicochemical propert...
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In the course of our screening program we have isolated from the culture fo Actinomadura carminata carminomycin, a new anthracycline antibiotic which possessed strong antitumor activity in animal experiments. It is produced as a mixture of several active components: the more interesting ones are components 1, 2 and 3. Components 2 and 3 can be transformed by means of mild hydrolysis into carmin...
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A new antitumor antibiotic, 3''-demethylchartreusin was isolated from the culture broth of Streptomyces chartreusis, as a minor component of crude chartreusin. It is structurally related to chartreusin, containing same aglycone of chartreusin, but different sugar moieties. 3''-Demethylchartreusin exhibits some potent inhibitory activities against murine tumors.
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Thrazarine, O-[(3R)-2-diazo-3-hydroxybutyryl)]-L-serine, is a new antitumor antibiotic produced by Streptomyces coerulescens MH802-fF5. Thrazarine was isolated from culture filtrate by Sephadex LH-20 column chromatography and reversed phase HPLC. Thrazarine induced cytolysis of tumor cell lines co-cultured with nonactivated macrophages. This effect was tumor specific because the nontumorigenic ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1981
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.34.1402